Clean install db2, run 2.46.02Beta.
At startup you get the message that there is no settings file, but it's ok if it's a new install.
File->new simulation.
And you get; Subscript out of range. Program exits without generating any files.
edit:If you first run 2.45.01 and run a new simulation once and exit it does ok on running 2.46.02Beta.