Please don't use the term "allergy". What you are talking about is plain toxicity.
Nums, about your
One thing I just realized is that
If you can come up with a list of reactions that represents the majority of single steps in: blah-blah
I can do it, but this is a lot of work.
About primitive metabolisms - does it matter where the energy to organism is coming from? For some it comes from light, for others - from chemical compounds, but in the end it is just a way to grab some energy from environment - the further steps are quite similar. I am too lazy to figure all that stuff out.
How about this - I make up a set of rules for basic plants and higher animals. If other people want, they can always
add to that.
P.S: I'll include the CO2, O2, H2O, but... you know...