No, you go into the Global Settings tab and put checkmarks in all the boxes on the mutations tab, then you have to click start/change and then quit DB for those settings to take affect.
Next time you start DB you start new sims with A and B instances like before, but you will now run with the new mutation features.
I've doing tests where I started off with your template as I call it, then I've added stuff/settings a few at a time to figure out where the teleporter problems begins.
So far I seem to have narrowed it down to be the "Epigenetic Reset" and/or "Normalize default mutation rates..." to be what's messing up the teleporting.
We're getting closer! It's getting hot!