Which version of DB?
There have been a bunch of changes to the mutations panel lately. In the later 2.36 versions the panel has a button that disables mutations. I am not sure if the F1 mode toggle is set to automatically set this to "disabled". In fact I am almost certain that it doesn't since I don't remember setting it up that way.
It is probably best that you manually disable mutations for each bot before activating F1 mode till we get this sorted.